Musunuru Laboratory

Our goal is to understand how human genetic variation protects or predisposes some people to myocardial infarction, sudden cardiac death, and other cardiovascular disorders and to use that information to prevent disease.

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SCRB 150 (formerly MCB 150)

Human Genetics: Mining Our Genomes for an Understanding of Human Variation and Disease

Catalog Number: 5703
Kiran Musunuru
Half course (fall term). W., 2–5. EXAM GROUP: 7, 8, 9

The sequencing of the human genome has revealed the full extent of genetic variation that exists within us as a species. This genetic diversity underlies much of our physical variation as well as our differences in responsiveness to disease stimuli and their treatments. We will explore these and other ramifications of human genetic diversity by applying classical and contemporary genetic tools to the identification of specific genes and pathways that functionally underlie our variable biology.
Prerequisite: Life and Physical Sciences A or Life Sciences 1a; Life Sciences 1b (or equivalent); SCRB 10 or MCB 52. Not expected to be offered in 2014-2015.

SCRB 25

Biochemistry and Human Metabolism

Catalog Number: 57725
Kiran Musunuru
Half course (spring term). Tu., Th., 2:30–4. EXAM GROUP: 16, 17

This course provides an introduction to the principles of biochemistry in the context of human physiology and disease. We will investigate biochemical pathways governing the metabolism of proteins, carbohydrates, fatty acids and lipids, and nucleic acids. Additionally, we will address basic enzymology, bioenergetics, energy storage and release, and hormonal regulation of metabolism. Special emphasis will be given to the impact of biochemical pathways on disease as well as the development of new therapies.
Prerequisite: LPS A or LS 1a or equivalent.

Genetics 220

Molecular Biology and Genetics in Modern Medicine

Catalog Number: 4660
Kiran Musunuru
Primarily for Graduates. Half course (fall term). Tu., 2–5, F., 8:30–12:30.

This course will provide a firm foundation for understanding the relationship between molecular biology, developmental biology, genetics, genomics, bioinformatics, and medicine. The goal is to develop explicit connections between basic research, medical understanding, and the perspective of patients. During the course the principles of human genetics will be reviewed. Students will become familiar with the translation of clinical understanding into analysis at the level of the gene, chromosome and molecule, the concepts and techniques of molecular biology and genomics, and the strategies and methods of genetic analysis, including an introduction to bioinformatics. The course will extend beyond basic principles to current research activity in human genetics.
Note: Offered jointly with the Medical School as HT 160.

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