Eggan Lab

2016 Sep 25

10 Years of iPSCs

Mon - Wed, Sep 25 to Sep 27, 8:00am - 6:00pm

Location: 

Claremont Hotel & Spa, 41 Tunnel Road, Berkeley, CA

*Cell Symposia* *Keynote addresses by:* /*Shinya Yamanaka*/ and /*Rudolf Jaenisc*/h In 2006, Shinya Yamanaka and Kazutoshi Takahashi reported the Nobel Prize winning discovery of induced pluripotent stem cells (iPSCs) in Cell. In the ten years that have passed since, iPSC technology has provided fundamental insights into our understanding of cell fate, mammalian development, and human disease. It has also spurred renewed interest in direct reprogramming across lineages, and this area too has flourished.

Suzuki N, Maroof AM, Merkle FT, Koszka K, Intoh A, Armstrong I, Moccia R, Davis-Dusenbery BN, Eggan K. The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD. Nat Neurosci. 2013;16 (12) :1725-7. PMCID: PMC4397902.Abstract

Using transgenic mice harboring a targeted LacZ insertion, we studied the expression pattern of the C9ORF72 mouse ortholog (3110043O21Rik). Unlike most genes that are mutated in amyotrophic lateral sclerosis (ALS), which are ubiquitously expressed, the C9ORF72 ortholog was most highly transcribed in the neuronal populations that are sensitive to degeneration in ALS and frontotemporal dementia. Thus, our results provide a potential explanation for the cell type specificity of neuronal degeneration caused by C9ORF72 mutations.

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